In general, topical sulfur is well tolerated when used as directed. Undesirable effects are most likely to occur when sulfur is applied to broken skin and/or for a longer period of time. The following undesirable effects have been observed after using topical sulfur: Local irritation of the skin, eyes or respiratory tract; Skin inflammation (which may severe); Clogging of pores producing blackheads and whiteheads; Rare cases of allergic reactions; Systemic toxicity and several deaths after topical use of sulfur 10% ointment for 3 days in babies with scabies; Sulfur stains clothing, bedding, and metal (e.g., silver and copper), including jewelry.